Tick saliva suppresses IFN signalling in dendritic cells upon Borrelia afzelii infection

0375992 - BC 2013 RIV GB eng J - Článek v odborném periodiku
Lieskovská, Jaroslava - Kopecký, Jan
Tick saliva suppresses IFN signalling in dendritic cells upon Borrelia afzelii infection.
Parasite immunology. Roč. 34, č. 1 (2012), s. 32-39. ISSN 0141-9838. E-ISSN 1365-3024
Grant CEP: GA MŠMT(CZ) LC06009
Institucionální podpora: RVO:60077344
Klíčová slova: Borrelia * dendritic cells * interferon signalling * tick saliva
Kód oboru RIV: EC - Imunologie
Impakt faktor: 2.208, rok: 2012

Type I interferons (IFN-a and IFN-beta) are crucial determinants of the host immune response and tick saliva modulates this response, thus facilitating the transmission of tickborne pathogens. The current study therefore examines the effect of Ixodes ricinus tick saliva on IFN-beta signalling in murine dendritic cells using lipopolysaccharide (LPS) and Borrelia afzelii spirochaetes as inducers. Our results show that Borrelia-induced activation of STAT-1 was suppressed by tick saliva. Our data indicate that similar to I. ricinus tick saliva may modulate the host immune response by attenuating the initial signal transduction pathway of type I IFN.
Trvalý link: http://hdl.handle.net/11104/0208513