Waves of gene regulation suppress and then restore oxidative phosphorylation in cancer cells

0370173 - FGÚ 2012 RIV GB eng J - Článek v odborném periodiku
Smolková, Katarína - Plecitá-Hlavatá, Lydie - Bellance, N. - Benard, G. - Rossignol, R. - Ježek, Petr
Waves of gene regulation suppress and then restore oxidative phosphorylation in cancer cells.
International Journal of Biochemistry and Cell Biology. Roč. 43, č. 7 (2011), s. 950-968. ISSN 1357-2725. E-ISSN 1878-5875
Grant CEP: GA MZd NR7778; GA MŠMT(CZ) ME09029; GA AV ČR(CZ) IAA500110701
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: metabolic changes * mitochondria * carcinogenesis
Kód oboru RIV: ED - Fyziologie
Impakt faktor: 4.634, rok: 2011

In this review authors posit following hypothesis: Independently of whether malignant tumors are initiated by a fundamental reprogramming of gene expression or seeded by stem cells, waves of gene expression that promote metabolic changes occur during carcinogenesis, beginning with oncogene-mediated changes, followed by hypoxia-induced factor (HIF)-mediated gene expression, both resulting in the highly glycolytic Warburg phenotype and suppression of mitochondrial biogenesis
Trvalý link: http://hdl.handle.net/11104/0204050