4'-Alkoxy oligodeoxynucleotides: a novel class of RNA mimics

0369807 - ÚOCHB 2012 RIV GB eng J - Článek v odborném periodiku
Liboska, Radek - Snášel, Jan - Barvík, I. - Buděšínský, Miloš - Pohl, Radek - Točík, Zdeněk - Páv, Ondřej - Rejman, Dominik - Novák, Pavel - Rosenberg, Ivan
4'-Alkoxy oligodeoxynucleotides: a novel class of RNA mimics.
Organic & Biomolecular Chemistry. Roč. 9, č. 24 (2011), s. 8261-8267. ISSN 1477-0520. E-ISSN 1477-0539
Grant CEP: GA ČR GA202/09/0193; GA AV ČR KAN200520801; GA MŠMT(CZ) LC06061
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: 4'-alkoxy oligothymidylates * modified oligonucleotides * oligonucleotide hybridisation * RNA mimics
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 3.696, rok: 2011

4´-Alkoxy-oligothymidylates were prepared as model compounds to study the influence of a C4´-alkoxy group on hybridisation. The phosphodiester homooligomers (15 units long) containing either a 4´-methoxy or 4´-(2-methoxyethoxy) group were found to display increased hybridisation with both dA15 and rA15 complementary counterparts compared to the natural oligothymidylate. In addition, their hybridisation behaviour was found to be similar to that of the regioisomeric 2´-O-methyl-oligothymidylate. The 4´-alkoxy modified nucleotides seem to be promising compounds for assembly of chimeric oligonucleotides with tunable properties.
Trvalý link: http://hdl.handle.net/11104/0203789