Highly superporous cholesterol-modified poly(2-hydroxyethyl methacrylate) scaffolds for spinal cord injury repair

0368381 - ÚEM 2012 RIV US eng J - Článek v odborném periodiku
Kubinová, Šárka - Horák, Daniel - Hejčl, Aleš - Plichta, Zdeněk - Kotek, Jiří - Syková, Eva
Highly superporous cholesterol-modified poly(2-hydroxyethyl methacrylate) scaffolds for spinal cord injury repair.
Journal of Biomedical Materials Research. Part A. Roč. 99, č. 4 (2011), s. 618-629. ISSN 1549-3296. E-ISSN 1552-4965
Grant CEP: GA AV ČR IAA500390902; GA ČR GAP304/11/0731; GA ČR(CZ) GPP304/11/P633
Grant ostatní: GA AV ČR(CZ) KAN200520804; GA ČR(CZ) GAP108/10/1560; GA ČR(CZ) GAP304/11/0653; GA MŠk(CZ) 1M0538
Program: KA; GA; GA; 1M
Výzkumný záměr: CEZ:AV0Z50390703; CEZ:AV0Z40500505
Klíčová slova: 2-hydroxyethyl methacrylate * scaffold * spinal cord repair
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 2.625, rok: 2011

Modifications of poly(2-hydroxyethyl methacrylate) (PHEMA) with cholesterol and the introduction of large pores can serve as a permissive scaffold for spinal cord injury treatment. The hydrogels supported the in vitro adhesion and proliferation of rat mesenchymal stem cells. In an in vivo study of acute rat spinal cord injury, hydrogels were implanted to bridge a hemisection cavity. Histological revealed the good incorporation of the implanted hydrogels into the surrounding tissue, the progressive infiltration of connective tissue and the ingrowth of neurofilaments, Schwann cells and blood vessels into the hydrogel pores. The results show that highly superporous cholesterol-modified PHEMA hydrogels have bioadhesive properties and are able to bridge a spinal cord lesion.
Trvalý link: http://hdl.handle.net/11104/0202742