Novel polymeric nanoparticles assembled by metal ion addition

0366448 - ÚMCH 2012 RIV DE eng J - Článek v odborném periodiku
Škodová, Michaela - Hrubý, Martin - Filippov, Sergey K. - Karlsson, G. - Macková, Hana - Špírková, Milena - Kaňková, Dana - Steinhart, Miloš - Štěpánek, Petr - Ulbrich, Karel
Novel polymeric nanoparticles assembled by metal ion addition.
Macromolecular Chemistry and Physics. Roč. 212, č. 21 (2011), s. 2339-2348. ISSN 1022-1352. E-ISSN 1521-3935
Grant CEP: GA ČR GPP207/10/P054; GA ČR GA202/09/2078; GA MŠMT 1M0505
Výzkumný záměr: CEZ:AV0Z40500505
Klíčová slova: drug delivery systems * hydroxamic acid * nanoparticles
Kód oboru RIV: CD - Makromolekulární chemie
Impakt faktor: 2.361, rok: 2011

Potentially biodegradable graft polymer core-shell nanoparticles assembling by addition of metal ions intended to be used for radionuclide and drug delivery purposes are described. With Cu2+ ions, the self-assembly is slow (within minutes) with low efficiency. With Fe3+ ions the nanoparticles are formed immediately and are of convenient size for passive tumor accumulation by the enhanced permeation and retention effect. Full in vitro degradation of these particles is achieved with deferoxamine as a model of in vivo transchelation capacity.
Trvalý link: http://hdl.handle.net/11104/0201437