Cysteine proteases from bloodfeeding arthropod ectoparasites

0365983 - BC 2012 RIV US eng J - Článek v odborném periodiku
Sojka, Daniel - Francischetti, I.M.B. - Calvo, E. - Kotsyfakis, Michalis
Cysteine proteases from bloodfeeding arthropod ectoparasites.
Advances in Experimental Medicine and Biology. Roč. 712, - (2011), s. 177-191. ISSN 0065-2598. E-ISSN 2214-8019
Grant CEP: GA AV ČR IAA600960910; GA AV ČR IAA600960811; GA AV ČR KJB600960911; GA MŠMT(CZ) LC06009
Výzkumný záměr: CEZ:AV0Z60220518
Klíčová slova: TICK HAEMAPHYSALIS-LONGICORNIS * PROLIXUS STAL HEMIPTERA * YELLOW-FEVER MOSQUITO * BLOOD-MEAL DIGESTION * L-LIKE ENZYME * BOOPHILUS-MICROPLUS * RHODNIUS-PROLIXUS * CATHEPSIN-B * ASPARAGINYL ENDOPEPTIDASES/LEGUMAINS * PROTEOLYTIC ACTIVATION
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 1.093, rok: 2011

Cysteine proteases have been discovered in various bloodfeeding ectoparasites. Here, we assemble the available information about the function of these peptidases and reveal their role in hematophagy and parasite development. While most of the data shed light on key proteolytic events that play a role in arthropod physiology, we also report on the association of cysteine proteases with arthropod vectorial capacity. With emphasis on ticks, specifically Ixodes ricinus, we finally propose a model about the contribution of cysteine peptidases to blood digestion and how their concerted action with other tick midgut proteases leads to the absorbance of nutrients by the midgut epithelial cells.
Trvalý link: http://hdl.handle.net/11104/0201100