Neonatal colonization of mice with Lactobacillus plantarum producing the aeroallergen Bet v 1 biases towards Th1 and T-regulatory responses upon systemic sensitization

0361615 - MBÚ 2012 RIV DK eng J - Článek v odborném periodiku
Schwarzer, Martin - Repa, A. - Daniel, C. - Schabussova, I. - Hrnčíř, Tomáš - Pot, B. - Štěpánková, Renata - Hudcovic, Tomáš - Pollak, A. - Tlaskalová, Helena - Wiedermann, U. - Kozáková, Hana
Neonatal colonization of mice with Lactobacillus plantarum producing the aeroallergen Bet v 1 biases towards Th1 and T-regulatory responses upon systemic sensitization.
Allergy. Roč. 66, č. 3 (2011), 368-375. ISSN 0105-4538. E-ISSN 1398-9995
Grant CEP: GA AV ČR IAA500200710; GA ČR GA303/09/0449; GA MŠMT 2B06155
Výzkumný záměr: CEZ:AV0Z50200510
Klíčová slova: germ-free mice * allergy * mucosal immunity
Kód oboru RIV: EC - Imunologie
Impakt faktor: 6.271, rok: 2011

The use of recombinant lactic acid bacteria (LAB) as vehicles for mucosal delivery of recombinant allergens is an attractive concept for antigen-defined allergy prevention/treatment. Interventions with LAB are of increasing interest early in life when immune programming is initiated. Here, we investigated the effect of neonatal colonization with a recombinant LAB producing the major birch pollen allergen Bet v 1 in a murine model of type I allergy
Trvalý link: http://hdl.handle.net/11104/0198892