Dendri-RAFTs: a second generation of cyclopeptide-based glycoclusters

0360704 - MBÚ 2012 RIV GB eng J - Článek v odborném periodiku
Bossu, I. - Šulc, Miroslav - Křenek, Karel - Dufour, E. - Garcia, J. - Berthet, N. - Dumy, P. - Křen, Vladimír - Renaudet, O.
Dendri-RAFTs: a second generation of cyclopeptide-based glycoclusters.
Organic & Biomolecular Chemistry. Roč. 9, č. 6 (2011), 1948-1959. ISSN 1477-0520. E-ISSN 1477-0539
Grant CEP: GA MŠMT(CZ) LC06010; GA ČR GD305/09/H008
Výzkumný záměr: CEZ:AV0Z50200510
Klíčová slova: T-CELL EPITOPE * CHEMOSELECTIVE LIGATION * B-CELL
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 3.696, rok: 2011

Synthetic glycoclusters and their related biological applications have stimulated increasing interest over the last decade. As a prerequisite to discovering active and selective therapeuticals, the development of multivalent glycoconjugates with diverse topologies is faced with inherent synthetic and structural characterisation difficulties. Here we describe a new series of molecularly-defined glycoclusters that were synthesized in a controlled manner using a robust and versatile divergent protocol
Trvalý link: http://hdl.handle.net/11104/0198192