Activated CD8+T cells contribute to clearance of gastric Cryptosporidium muris infections

0359447 - BC 2012 RIV GB eng J - Článek v odborném periodiku
Kváč, Martin - Lӧvy, Alena - Sak, Bohumil - Květoňová, Dana - Jalovecká, M. - Rost, M. - Salát, Jiří
Activated CD8+T cells contribute to clearance of gastric Cryptosporidium muris infections.
Parasite immunology. Roč. 33, č. 4 (2011), 210-216. ISSN 0141-9838. E-ISSN 1365-3024
Grant CEP: GA AV ČR KJB500960701
Výzkumný záměr: CEZ:AV0Z60220518
Klíčová slova: CD4+T-lymphocytes * CD8+T-lymphocytes * Cryptosporidium muris * T-cell-mediated immunity
Kód oboru RIV: EC - Imunologie
Impakt faktor: 2.601, rok: 2011

The role of CD4+ and CD8+ T lymphocytes in the development of a protective immune response against Cryptosporidium muris infection was studied by the reconstitution of severe combined immunodeficient (SCID) mice with well-defined populations of either naive or immune CD8+ or CD4+ T lymphocytes. Adoptive transfer of both naive and immune CD4+ T lymphocyte subpopulations protects SCID mice against cryptosporidiosis. Moreover, a significant biological impact of activated CD8+ T cells against gastric cryptosporidiosis was observed. Thus, although CD4+ T cells are considered important in protective immunity, our results are the first to demonstrate the involvement of activated CD8+ T lymphocytes in the protection of mice against gastric cryptosporidiosis.
Trvalý link: http://hdl.handle.net/11104/0197236