CD161 receptor participates in both impairing NK cell cytotoxicity and the response to glycans and vimentin in patients with rheumatoid arthritis

0350375 - MBÚ 2011 RIV US eng J - Článek v odborném periodiku
Richter, Jan - Benson, Veronika - Grobárová, Valeria - Svoboda, Jan - Vencovský, J. - Svobodová, R. - Fišerová, Anna
CD161 receptor participates in both impairing NK cell cytotoxicity and the response to glycans and vimentin in patients with rheumatoid arthritis.
Clinical Immunology. Roč. 136, č. 1 (2010), s. 139-147. ISSN 1521-6616. E-ISSN 1521-7035
Grant CEP: GA ČR GA310/06/0477; GA ČR GD310/08/H077; GA MZd NR9106; GA AV ČR IAA500200620
Výzkumný záměr: CEZ:AV0Z50200510
Klíčová slova: Rheumatoid arthritis * NK cells * CD161
Kód oboru RIV: EC - Imunologie
Impakt faktor: 3.932, rok: 2010

High levels of CD161 receptor of NK cells are correlated with impairment of NK cytotoxic activity in RA patients. We propose that MCV plays an important role in RA by increasing expression of CD161, which leads to inhibition of NK cell activity and, consequently, insufficient downregulation of autoreactive T cell, thus accelerating disease progression
Trvalý link: http://hdl.handle.net/11104/0190392