Pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy

0349834 - ÚEB 2011 RIV US eng P - Patentový dokument
Moravcová, Daniela - Havlíček, Libor - Kryštof, Vladimír - Lenobel, René - Strnad, Miroslav
Pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy.
USA: United States Patent and Trademark Office, 2010. Vlastník: Ústav experimentální botaniky AV ČR, v. v. i., Univerzita Palackého v Olomouci. Datum podání přihlášky: 28.09.2004. Datum udělení patentu: 29.06.2010. Číslo patentu: US7745450
Grant CEP: GA ČR GA301/08/1649; GA ČR GA522/09/1576
Klíčová slova: pyrazolo[4,3-d]pyrimidines * anticancer * anti-inflamatory
Kód oboru RIV: FD - Onkologie a hematologie
http://v3.espacenet.com/publicationDetails/originalDocument?CC=US&NR=7745450B2&KC=B2&FT=D&date=20100629&DB=EPODOC&locale=en_EP http://arl-repository.lib.cas.cz/uloziste_av/UEB-Q/cav_un_epca-0349834_01.pdf

The invention relates to new trisubstituted pyrazolo[4,3-d]pyrimidine derivatives and to their use in suitable utilities, especially diagnostic and therapeutic methods.The compounds are anticancer, anti-inflammatory, antiviral, antineurodegenerative, neurodepressive and immunosuppressive, they have improved selectivity and efficiency index, i.e. that are less toxic yet more efficacious than analogues known.It is an object of this invention to provide 3-, 5-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines, which inhibit the cdks, cell proliferation, and/or induce apoptosis. A further object of the invention is to provide a method for inhibiting cell proliferation and inflammatory diseases to a mammal in need of an effective amount.The solution of this object are 3-, 5-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines of the formula I.
Trvalý link: http://hdl.handle.net/11104/0189973