Genetic polymorphisms influence the susceptibility of men to sperm DNA damage associated with exposure to air pollution

0340197 - ÚEM 2010 RIV NL eng J - Článek v odborném periodiku
Rubeš, J. - Rybář, R. - Přinosilová, P. - Věžník, Z. - Chvátalová, Irena - Solanský, I. - Šrám, Radim
Genetic polymorphisms influence the susceptibility of men to sperm DNA damage associated with exposure to air pollution.
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. Roč. 683, 1-2 (2010), s. 9-15. ISSN 0027-5107
Grant CEP: GA AV ČR 1QS500390506
Výzkumný záměr: CEZ:AV0Z50390512; CEZ:AV0Z50390703
Klíčová slova: Gene-environment interaction * sperm chromatin structure assay * sperm DNA damage
Kód oboru RIV: DN - Vliv životního prostředí na zdraví
Impakt faktor: 3.204, rok: 2010

The impact of PAHs and VOCs on sperm quality in a group of city policemen in Prague during winter season (high exposure) compared to spring season (low exposure) were studied. Polymorphisms in metabolic genes (CYP1A1, EPHX1, GSTM1, GSTP1, GSTT1), folic acid metabolism genes (MTR, MTHFR) and DNA repair genes (XRCC1, XPD6, XPD23, hOGG1) were evaluated as potential modifiers of associations between air pollution exposure and changes in sperm quality. No significant differences were found in any standard semen parameters between the sampling periods except for vitality of sperms.
Trvalý link: http://hdl.handle.net/11104/0183490