Mass spectrometry as a tool for characterization of N,N-dialkylaminoethane-2-thiols - precursors and degradation products of chemical warfare agents

0339840 - ÚEB 2010 RIV GB eng J - Článek v odborném periodiku
Papoušková, B. - Bednář, P. - Stýskala, Jakub - Hlaváč, J. - Barták, P. - Lemr, K.
Mass spectrometry as a tool for characterization of N,N-dialkylaminoethane-2-thiols - precursors and degradation products of chemical warfare agents.
Journal of Mass Spectrometry. Roč. 44, č. 11 (2009), s. 1604-1612. ISSN 1076-5174. E-ISSN 1096-9888
Výzkumný záměr: CEZ:AV0Z50380511
Klíčová slova: mass spectrometry * chemical warfare agents * N,N-dialkylaminoethane-2-thiols
Kód oboru RIV: CE - Biochemie
Impakt faktor: 3.411, rok: 2009

N,N-dialkylaminoethane-2-thiols belong to the group of precursors and degradation products of chemical warfare agents (CWAs). These compounds were analyzed by means of electrospray ionization-multiple stage mass spectrometry (ion trap) and proposed fragments were confirmed by accurate mass measurement using a QqTOF system. The fragmentation pathways of studied compounds and the products of oxidation (formation of -S-S- linkage) were described. Some minor interesting processes, such as rearrangement of SH group, were observed and proved. A new mu LC/MS method, based on ion-pairing chromatography, was developed. Trifluoroacetic acid was employed as an ion-pairing agent to increase the low retention of compounds of interest in the reverse-phase system. The technique was compared with the UPLC/MS method, allowing fast analysis of all the studied thiols as well as an explorative control of originated disulfides.
Trvalý link: http://hdl.handle.net/11104/0183244