In vitro anti-inflammatory activity of carvacrol: Inhibitory effect on COX-2 catalyzed prostaglandin E-2 biosynthesis

0335925 - ÚEB 2010 RIV KR eng J - Článek v odborném periodiku
Landa, Přemysl - Kokoška, L. - Přibylová, Marie - Vaněk, Tomáš - Maršík, Petr
In vitro anti-inflammatory activity of carvacrol: Inhibitory effect on COX-2 catalyzed prostaglandin E-2 biosynthesis.
Archives of Pharmacal Research. Roč. 32, č. 1 (2009), s. 75-78. ISSN 0253-6269. E-ISSN 1976-3786
Grant CEP: GA ČR GA525/08/1179; GA MŠMT 1P04OC926.001
Výzkumný záměr: CEZ:AV0Z50380511
Klíčová slova: Carvacrol * Cyclooxygenase * Prostaglandin
Kód oboru RIV: GM - Potravinářství
Impakt faktor: 1.159, rok: 2009

Possible anti-inflammatory effect of carvacrol was evaluated by in vitro cyclooxygenase-2 (COX-2) assay. Carvacrol inhibited production of prostaglandin E-2 catalysed by COX-2 with an IC50 value of 0.8 mu M what is practically the same concentration as the IC50 obtained for the standard inhibitors indomethacin and NS-398 with values of 0.7 mu M and 0.8 mu M, respectively. The COX-1 was inhibited approximately at the same rate (IC50 of 0.7 mu M for carvacrol), which suggests non-selective inhibition of both enzyme isoforms. The results of the study demonstrate possible anti-inflammatory potential of this compound due to the inhibition of inducible COX-2 isoform.
Trvalý link: http://hdl.handle.net/11104/0180268