Porcine neuronal models that recapitulate HD pathogenesis in vitro

0329308 - ÚŽFG 2010 RIV IT eng C - Konferenční příspěvek (zahraniční konf.)
Hruška-Plocháň, Marian - Vodička, Petr - Lacková, Monika - Usvald, Dušan - Juhás, Štefan - Hrdličková, R. - Miyanohara, A. - Maršala, M. - Motlík, Jan
Porcine neuronal models that recapitulate HD pathogenesis in vitro.
IV. Meeting on the molecular mechanisms of neurodegeneration. Vol. P 50. Milano: Keyword Europa, 2009, s. 32-32.
[IV. Meeting on the molecular mechanisms of neurodegeneration. Miláno (IT), 08.05.2009-10.05.2009]
Grant CEP: GA MŠMT 1M0506
Výzkumný záměr: CEZ:AV0Z50450515
Klíčová slova: Huntington disease * porcine neuronal model
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy

Huntington disease is a fatal dominantly inherited neurodegenerative disease caused by the expansion of polyCAG stretch in gene coding ubiquitous huntingtin protein(htt). Selectively striatal neuronal loss followed by degemeration of cortex and other brain and non. neuronal regions occur in HD, but the function of mutated htt is not yet fully defined. The aim of this study is to develop porcine in vitro neuronal model that recapitulates major pathogenic steps in HD and would be much easily accessible than human cells and much closer to those primate origin that the rodent one
Trvalý link: http://hdl.handle.net/11104/0175380