Posttreatment with group II metabotropic glutamate receptor agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate is only weakly effective on seizures in immature rats

0327874 - FGÚ 2010 RIV NL eng J - Článek v odborném periodiku
Folbergrová, Jaroslava - Druga, Rastislav - Tsenov, Grygoriy - Haugvicová, Renata - Otáhal, Jakub
Posttreatment with group II metabotropic glutamate receptor agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate is only weakly effective on seizures in immature rats.
Brain Research. Roč. 1273, - (2009), s. 144-154. ISSN 0006-8993. E-ISSN 1872-6240
Grant CEP: GA ČR(CZ) GA309/05/2015; GA ČR GA309/08/0292; GA ČR(CZ) GA304/07/1137
Výzkumný záměr: CEZ:AV0Z50110509; CEZ:AV0Z50200510
Klíčová slova: DL-homocysteic acid-induced seizures * posttreatment with 2R * 4R-APDC * partial protection
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 2.463, rok: 2009

Anticonvulsant and neuroprotective effect of (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate, agonist for group II metabotropic glutamate receptors, was substantially reduced when given after the onset of seizures induced in immature rats by homocysteic acid. The severity of seizures, changes of brain energy metabolites and neuronal damage of hippocampus and thalamus were influenced only partially
Trvalý link: http://hdl.handle.net/11104/0174325