0194441 - UOCHB-X 20020108 RIV GB eng J - Článek v odborném periodiku
Evans, J. C. - Huddler, D. P. - Jiráček, Jiří - Castro, C. - Millian, N. S. - Garrow, T. A. - Ludwig, M. L.
Betaine-homocysteine methyltransferase: zinc in a distorted barrel.
Structure. Roč. 10, - (2002), s. 1159-1171. ISSN 0969-2126. E-ISSN 1878-4186
Grant CEP: GA AV ČR IAB4055003
Grant ostatní: NIH(US) GM16429; NIH(US) DK52501
Výzkumný záměr: CEZ:AV0Z4055905
Klíčová slova: homocysteine
Kód oboru RIV: CE - Biochemie
Impakt faktor: 6.030, rok: 2002

In this paper we describe the structure of BHMT in the oxidized (Zn-free) and reduced (Zn-replete) states. The structure of BHMT in complex with the transition-state mimic, S(ë-carboxybutyl)-L-homocysteine, has allowed us to define the interactions that are responsible for substrate binding and specificity.
Trvalý link: http://hdl.handle.net/11104/0090116