0587722 - FZÚ 2025 RIV CN eng J - Článek v odborném periodiku
Tesař, Karel - Luňáčková, J. - Jex, M. - Žaloudková, Margit - Vrbová, R. - Bartoš, M. - Klein, P. - Vištejnová, L. - Dušková, J. - Filová, Elena - Sucharda, Zbyněk - Steinerová, Marie - Habr, Stanislav - Balík, Karel - Singh, A.
In vivo and in vitro study of resorbable magnesium wires for medical implants: Mg purity, surface quality, Zn alloying and polymer coating.
Journal of Magnesium and Alloys. Roč. 12, č. 6 (2024), s. 2472-2488. ISSN 2213-9567. E-ISSN 2213-9567
Grant CEP: GA MŠMT(CZ) EH22_008/0004591; GA TA ČR(CZ) TP01010055
Grant ostatní: AV ČR(CZ) AP2202
Program: Akademická prémie - Praemium Academiae
Institucionální podpora: RVO:68378271 ; RVO:67985823 ; RVO:67985891
Klíčová slova: magnesium * resorbable Mg wire * Mg-Zn implant degradation * biocompatibility study * Zn grain boundary segregation
Obor OECD: Biomaterials (as related to medical implants, devices, sensors); Biomaterials (as related to medical implants, devices, sensors) (FGU-C); Biomaterials (as related to medical implants, devices, sensors) (USMH-B)
Impakt faktor: 15.8, rok: 2023 ; AIS: 1.966, rok: 2023
Způsob publikování: Open access
DOI: https://doi.org/10.1016/j.jma.2024.06.003

Magnesium is an excellent material in terms of biocompatibility and its corrosion products can serve as an active source for new bone formation. Utilizing low-alloyed Mg-Zn wires can strongly reduce problems with large H2 bubbles and improve the mechanical properties. Acidic pickling and a polymer coating can be effectively used to lower the rate of in vivo degradation. In this work, microstructural, mechanical, and in vitro characterization of 250 µm and 300 µm extruded wires made from ultra-pure Mg, commercially pure Mg, Mg-0.15Zn, Mg-0.4Zn and Mg-1Zn was performed. Additionally, Mg-0.4Zn wires together with a variant coated with a copolymer of l-lactide and ε-caprolactone were tested in vivo on artificially damaged Wistar rat femurs. Based on the observed Mg-induced osteogenesis, polymer-coated Mg wires with a small addition of Zn are a perspective material for bone-support applications, such as cerclage and fixation wires.
Trvalý link: https://hdl.handle.net/11104/0354828