mTOR pathway inhibition alters proliferation as well as differentiation of neural stem cells

0585864 - ÚEM 2025 RIV CH eng J - Článek v odborném periodiku
Romanyuk, Nataliya - Šintáková, Kristýna - Arzhanov, Ivan - Horák, Martin - Gandhi, Ch. - Jhanwar-Uniyal, M. - Jendelová, Pavla
mTOR pathway inhibition alters proliferation as well as differentiation of neural stem cells.
Frontiers in Cellular Neuroscience. Roč. 18, May (2024). E-ISSN 1662-5102
Grant CEP: GA MŠMT(CZ) LX22NPO5107
Institucionální podpora: RVO:68378041
Klíčová slova: neural stem cells * mTOR * proliferation * differentiation * cytoskeletal proteins
Obor OECD: Neurosciences (including psychophysiology
Impakt faktor: 5.3, rok: 2022
https://www.frontiersin.org/articles/10.3389/fncel.2024.1298182/full

Neural stem cells (NSCs) are essential for both embryonic development and adult neurogenesis, and their dysregulation causes a number of neurodevelopmental disorders, such as epilepsy and autism spectrum disorders. NSC proliferation and differentiation in the developing brain is a complex process controlled by various intrinsic and extrinsic stimuli. The mammalian target of rapamycin (mTOR) regulates proliferation and differentiation, among other cellular functions, and disruption in the mTOR pathway can lead to severe nervous system development deficits. In this study, we investigated the effect of inhibition of the mTOR pathway by rapamycin (Rapa) on NSC proliferation and differentiation.
Trvalý link: https://hdl.handle.net/11104/0353515