Počet záznamů: 1  

Mitochondrial Cristae Morphology Reflecting Metabolism, Superoxide Formation, Redox Homeostasis, and Pathology

  1. 1.
    0577681 - FGÚ 2024 RIV US eng J - Článek v odborném periodiku
    Ježek, Petr - Jabůrek, Martin - Holendová, Blanka - Engstová, Hana - Dlasková, Andrea
    Mitochondrial Cristae Morphology Reflecting Metabolism, Superoxide Formation, Redox Homeostasis, and Pathology.
    Antioxidants & Redox Signaling. Roč. 39, 10-12 (2023), s. 635-683. ISSN 1523-0864. E-ISSN 1557-7716
    Grant CEP: GA ČR(CZ) GA21-01205S; GA ČR(CZ) GA23-05798S; GA ČR(CZ) GA22-02203S; GA MŠMT(CZ) EF18_046/0016045
    Institucionální podpora: RVO:67985823
    Klíčová slova: mitochondrial cristae * mitochondrial superoxide formation * ATP-synthase dimeric rows * MICOS * OPA1 * respiratory chain supercomplexes
    Obor OECD: Physiology (including cytology)
    Impakt faktor: 5.9, rok: 2023
    Způsob publikování: Open access
    Web výsledku:
    https://doi.org/10.1089/ars.2022.0173DOI: https://doi.org/10.1089/ars.2022.0173

    Significance: Mitochondrial (mt) reticulum network in the cell possesses amazing ultramorphology of parallel lamellar cristae, formed by the invaginated inner mitochondrial membrane. Its non-invaginated part, the inner boundary membrane (IBM) forms a cylindrical sandwich with the outer mitochondrial membrane (OMM). Crista membranes (CMs) meet IBM at crista junctions (CJs) of mt cristae organizing system (MICOS) complexes connected to OMM sorting and assembly machinery (SAM). Cristae dimensions, shape, and CJs have characteristic patterns for different metabolic regimes, physiological and pathological situations.Recent Advances: Cristae-shaping proteins were characterized, namely rows of ATP-synthase dimers forming the crista lamella edges, MICOS subunits, optic atrophy 1 (OPA1) isoforms and mitochondrial genome maintenance 1 (MGM1) filaments, prohibitins, and others. Detailed cristae ultramorphology changes were imaged by focused-ion beam/scanning electron microscopy. Dynamics of crista lamellae and mobile CJs were demonstrated by nanoscopy in living cells. With tBID-induced apoptosis a single entirely fused cristae reticulum was observed in a mitochondrial spheroid.Critical Issues: The mobility and composition of MICOS, OPA1, and ATP-synthase dimeric rows regulated by post-translational modifications might be exclusively responsible for cristae morphology changes, but ion fluxes across CM and resulting osmotic forces might be also involved. Inevitably, cristae ultramorphology should reflect also mitochondrial redox homeostasis, but details are unknown. Disordered cristae typically reflect higher superoxide formation.Future Directions: To link redox homeostasis to cristae ultramorphology and define markers, recent progress will help in uncovering mechanisms involved in proton-coupled electron transfer via the respiratory chain and in regulation of cristae architecture, leading to structural determination of superoxide formation sites and cristae ultramorphology changes in diseases.
    Trvalý link: https://hdl.handle.net/11104/0346809
     
Počet záznamů: 1  

  Tyto stránky využívají soubory cookies, které usnadňují jejich prohlížení. Další informace o tom jak používáme cookies.