Počet záznamů: 1  

Peptide analysis of tooth enamel A sex estimation tool for archaeological, anthropological, or forensic research

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    0574565 - FGÚ 2024 RIV US eng J - Článek v odborném periodiku
    Mikšík, I. - Morvan, Marine - Brůžek, J.
    Peptide analysis of tooth enamel A sex estimation tool for archaeological, anthropological, or forensic research.
    Journal of Separation Science. Roč. 46, č. 15 (2023), č. článku 2300183. ISSN 1615-9306. E-ISSN 1615-9314
    Grant CEP: GA ČR(CZ) GA20-03899S
    Institucionální podpora: RVO:67985823
    Klíčová slova: archeology * sex determination * tooth enamel
    Obor OECD: Analytical chemistry
    Impakt faktor: 3.1, rok: 2022
    Způsob publikování: Omezený přístup
    https://doi.org/10.1002/jssc.202300183

    Proteomics has become an attractive method to study human and animal material, biological profile, and origin as an alternative to DNA analysis. It is limited by DNA amplification in ancient samples and its contamination, high cost, and limited preservation of nuclear DNA. Currently, three approaches are available to estimate sex-osteology, genomics, or proteomics, but little is known about the relative reliability of these methods in applied settings. Proteomics provides a new, seemingly simple, and relatively non-expensive way of sex estimation without the risk of contamination. Proteins can be preserved in hard teeth tissue (enamel) for tens of thousands of years. It uses two sexually distinct forms of the protein amelogenin in tooth enamel detectable by liquid chromatography-mass spectrometry, the protein amelogenin Y isoform is present in enamel dental tissue only in males, while amelogenin isoform X can be found in both sexes. From the point of view of archaeological, anthropological, and forensic research and applications, the reduced destruction of the methods used is essential, as well as the minimum requirements for sample size.
    Trvalý link: https://hdl.handle.net/11104/0344800

     
     
Počet záznamů: 1  

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