0573836 - FGÚ 2024 RIV GB eng J - Článek v odborném periodiku
Levčík, David - Sugi, A. H. - Aquilar-Rivera, M. - Pochapski, J. A. - Baltazar, G. - Pulido, L. N. - Villas-Boas, C. A. - Fuentes-Flores, R. - Nicola, S. M. - Da Cunha, C.
Nucleus Accumbens Shell Neurons Encode the Kinematics of Reward Approach Locomotion.
Neuroscience. Roč. 524, 1 August (2023), s. 181-196. ISSN 0306-4522. E-ISSN 1873-7544
Grant CEP: GA ČR(CZ) GA20-00939S
Institucionální podpora: RVO:67985823
Klíčová slova: nucleus accumbens * reward approach * kinematics encoding * locomotor speed * initiation of action
Obor OECD: Neurosciences (including psychophysiology
Impakt faktor: 2.9, rok: 2023
Způsob publikování: Omezený přístup
https://doi.org/10.1016/j.neuroscience.2023.06.002

The nucleus accumbens (NAc) is considered an interface between motivation and action, with NAc neurons playing an important role in promoting reward approach. However, the encoding by NAc neurons that contributes to this role remains unknown. We recorded 62 NAc neurons in male Wistar rats (n = 5) running towards rewarded locations in an 8-arm radial maze. Variables related to locomotor approach kinematics were the best predictors of the firing rate for most NAc neurons. Nearly 18% of the recorded neurons were inhibited during the entire approach run (locomotion-off cells), suggesting that reduction in firing of these neurons promotes initiation of locomotor approach. 27% of the neurons presented a peak of activity during acceleration followed by a valley during deceleration (acceleration-on cells). Together, these neurons accounted for most of the speed and acceleration encoding identified in our analysis. In contrast, a further 16% of neurons presented a valley during acceleration followed by a peak just prior to or after reaching reward (deceleration-on cells). These findings suggest that these three classes of NAc neurons influence the time course of speed changes during locomotor approach to reward.
Trvalý link: https://hdl.handle.net/11104/0344191