Počet záznamů: 1  

Light-induced antifungal activity of nanoparticles with an encapsulated porphyrin photosensitizer

  1. 1.
    0570223 - FGÚ 2024 RIV DE eng J - Článek v odborném periodiku
    Kodedová, Marie - Liška, V. - Mosinger, J. - Sychrová, Hana
    Light-induced antifungal activity of nanoparticles with an encapsulated porphyrin photosensitizer.
    Microbiological Research. Roč. 269, April (2023), č. článku 127303. ISSN 0944-5013. E-ISSN 1618-0623
    Grant CEP: GA MŠk(CZ) LTC20005
    Institucionální podpora: RVO:67985823
    Klíčová slova: photodynamic therapy * nanoparticles * singlet oxygen * porphyrin * Candida * yeast
    Obor OECD: Microbiology
    Impakt faktor: 6.7, rok: 2022
    Způsob publikování: Omezený přístup
    https://doi.org/10.1016/j.micres.2023.127303

    The strong antifungal effect of sulfonated polystyrene nanoparticles (NPs) with an encapsulated tetraphe-nylporphyrin (TPP) photosensitizer is reported here. TPP is activated by visible light, resulting in the generation of singlet oxygen. Its antifungal action is potentiated in the presence of potassium iodide, yielding I2/I3-, another antifungal species. The NPs exhibit no dark toxicity, but a broad spectrum of antifungal photodynamic effects. The efficiency of this rapid killing (on the order of minutes) depends on the concentration of TPP NPs, potassium iodide, yeast species and temperature. A strong antifungal activity of TPP NPs is demonstrated on eleven pathogenic and opportunistic pathogenic yeast species (six Candida species and other yeast species, including melanized Hortaea werneckii). The composition and architecture of yeast cell envelope structures clearly influ-ence the efficacy of photodynamic therapy. Candida krusei is the most sensitive to photodynamic therapy. Despite expectations, melanin does not provide Hortaea cells with marked resistance compared to white yeast species. The kinetics of the interaction of NPs with yeast cells is also described. This study may inspire and promote the fabrication of a new type of antiseptic for various skin injuries in clinical medicine.
    Trvalý link: https://hdl.handle.net/11104/0341699

     
     
Počet záznamů: 1  

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