Multimodal contrast agent enabling pH sensing based on organically functionalized gold nanoshells with Mn-Zn ferrite cores

0563784 - FZÚ 2023 RIV CH eng J - Článek v odborném periodiku
Bui, Duong Thuy - Havelek, R. - Královec, K. - Kubíčková, Lenka - Kuličková, Jarmila - Matouš, P. - Herynek, V. - Kupčík, Jaroslav - Muthná, D. - Řezanka, P. - Kaman, Ondřej
Multimodal contrast agent enabling pH sensing based on organically functionalized gold nanoshells with Mn-Zn ferrite cores.
Nanomaterials. Roč. 12, č. 3 (2022), č. článku 428. E-ISSN 2079-4991
Grant CEP: GA MŠMT(CZ) EF16_019/0000760; GA ČR GA18-13323S; GA MŠMT(CZ) LM2018096
Grant ostatní: OP VVV - SOLID21(XE) CZ.02.1.01/0.0/0.0/16_019/0000760
Výzkumná infrastruktura: CzechNanoLab - 90110
Institucionální podpora: RVO:68378271
Klíčová slova: gold nanoshells * magnetic nanoparticles * surface-enhanced Raman spectroscopy * photoacoustic imaging * transverse relaxivity * cell viability
Obor OECD: Nano-materials (production and properties)
Impakt faktor: 5.3, rok: 2022
Způsob publikování: Open access

Gold nanoshells with magnetic cores and complex organic functionalization may offer an efficient multimodal platform for MRI, photoacoustic imaging (PAI), and fluorescence techniques combined with pH sensing by SERS. In the present study, the synthesis of gold nanoshells with Mn-Zn ferrite cores is described, and their properties are analyzed by XRD, XRF, TEM, magnetic measurements, and UV-Vis spectroscopy. The gold surface is functionalized with four different model molecules to analyze the effect of varying charge and surface chemistry on cells in vitro. Finally, the nanoshells are functionalized with a combination of 4-mercaptobenzoic acid and 7-mercapto-4-methylcoumarin, which introduces a SERS active pH sensor and a covalently attached fluorescent tag. NMR relaxometry, fluorescence spectroscopy, and PAI demonstrate the multimodal potential of the suggested probe, including extraordinarily high transverse relaxivity, while the SERS study evidences a pH-dependent spectral response.

Trvalý link: https://hdl.handle.net/11104/0335589