Ruthenium(II) Complex Containing a Redox-Active Semiquinonate Ligand as a Potential Chemotherapeutic Agent: From Synthesis to In Vivo Studies

0559781 - ÚMG 2023 RIV US eng J - Článek v odborném periodiku
Notaro, A. - Frei, A. - Rubbiani, R. - Jakubaszek, M. - Basu, U. - Koch, S. - Mari, C. - Dotou, M. - Blacque, O. - Gouyon, J. - Bedioui, F. - Rotthowe, N. - Winter, R. F. - Goud, B. - Ferrari, Stefano - Tharaud, M. - Řezáčová, M. - Humajová, J. - Tomsik, P. - Gasser, G.
Ruthenium(II) Complex Containing a Redox-Active Semiquinonate Ligand as a Potential Chemotherapeutic Agent: From Synthesis to In Vivo Studies.
Journal of Medicinal Chemistry. Roč. 63, č. 10 (2020), s. 5568-5584. ISSN 0022-2623. E-ISSN 1520-4804
Grant CEP: GA ČR GA17-02080S
Institucionální podpora: RVO:68378050
Klíčová slova: Cellular uptake * Cancer-therapy * Charge-distribution
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 7.446, rok: 2020
Způsob publikování: Omezený přístup
https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00431

Chemotherapy remains one of the dominant treatments to cure cancer. However, due to the many inherent drawbacks, there is a search for new chemotherapeutic drugs. Many classes of compounds have been investigated over the years to discover new targets and synergistic mechanisms of action including multicellular targets. In this work, we designed a new chemotherapeutic drug candidate against cancer, namely, Ru(DIP)(2)(sq)](PF6) (Ru-sq) (DIP = 4,7-diphenyl-1,10-phenanthroline, sq = semiquinonate ligand). The aim was to combine the great potential expressed by Ru(II) polypyridyl complexes and the singular redox and biological properties associated with the catecholate moiety. Experimental evidence (e.g., X-ray crystallography, electron paramagnetic resonance, electrochemistry) demonstrates that the semiquinonate is the preferred oxidation state of the dioxo ligand in this complex. The biological activity of Ru-sq was then scrutinized in vitro and in vivo, and the results highlight the promising potential of this complex as a chemotherapeutic agent against cancer.
Trvalý link: https://hdl.handle.net/11104/0332983