Fluorinated diselenide nanoparticles for radiosensitizing therapy of cancer

0557919 - ÚMCH 2023 RIV US eng J - Článek v odborném periodiku
Vetrík, Miroslav - Kučka, Jan - Kobera, Libor - Konefal, Rafal - Lobaz, Volodymyr - Pavlova, Ewa - Báječný, M. - Heizer, T. - Brus, Jiří - Šefc, L. - Pratx, G. - Hrubý, Martin
Fluorinated diselenide nanoparticles for radiosensitizing therapy of cancer.
Free Radical Biology and Medicine. Roč. 187, July (2022), s. 132-140. ISSN 0891-5849. E-ISSN 1873-4596
Grant CEP: GA MŠMT(CZ) LTC19032; GA ČR(CZ) GA21-01090S
Grant ostatní: AV ČR(CZ) DAAD-19-09; AV ČR(CZ) MSM200501801
Program: Bilaterální spolupráce; Program na podporu mezinárodní spolupráce začínajících výzkumných pracovníků
Výzkumná infrastruktura: Czech-BioImaging II - 90129
Institucionální podpora: RVO:61389013
Klíčová slova: diselenide * fluorosomes * self-assembly nanoparticles
Obor OECD: Polymer science
Impakt faktor: 7.4, rok: 2022
Způsob publikování: Omezený přístup
https://www.sciencedirect.com/science/article/pii/S0891584922001988?via%3Dihub

Radiation resistance of cancer cells represents one of the major challenges in cancer treatment. The novel self-assembled fluoralkylated diselenide nanoparticles (fluorosomes) based on seleno-l-cystine (17FSe2) possess redox-active properties that autocatalytically decompose hydrogen peroxide (H2O2) and oxidize the intracellular glutathione (GSH) that results in regulation of cellular oxidative stress. Alkylfluorinated diselenide nanoparticles showed a significant cytotoxic and radiosensitizing effect on cancer cells. The EL-4 tumor-bearing C56BL/6 mice treated with 17FSe2 followed by fractionated radiation treatment (4 × 2Gy) completely suppressed tumor growth. Our results suggest that described diselenide system behaves as a potent radiosensitizer agent targeting tumor growth and preventing tumor recurrence.
Trvalý link: http://hdl.handle.net/11104/0332055