Počet záznamů: 1
Poly(4-styrenesulfonic acid-co-maleic anhydride)-coated NaGdF4:Yb,Tb,Nd nanoparticles with luminescence and magnetic properties for imaging of pancreatic islets and beta-cells
- 1.0556879 - ÚMCH 2023 RIV US eng J - Článek v odborném periodiku
Shapoval, Oleksandr - Engstová, Hana - Jirák, D. - Drahokoupil, Jan - Sulková, K. - Berková, Z. - Pop-Georgievski, Ognen - Holendová, Blanka - Ježek, Petr - Horák, Daniel
Poly(4-styrenesulfonic acid-co-maleic anhydride)-coated NaGdF4:Yb,Tb,Nd nanoparticles with luminescence and magnetic properties for imaging of pancreatic islets and beta-cells.
ACS Applied Materials and Interfaces. Roč. 14, č. 16 (2022), s. 18233-18247. ISSN 1944-8244. E-ISSN 1944-8252
Grant CEP: GA ČR(CZ) GA21-04420S; GA MŠk(CZ) EF16_019/0000760; GA MŠk(CZ) LM2018129; GA ČR(CZ) GA20-07313S
Výzkumná infrastruktura: Czech-BioImaging II - 90129
Institucionální podpora: RVO:61389013 ; RVO:67985823 ; RVO:68378271
Klíčová slova: nanoparticles * gadolinium fluoride * luminescence
Obor OECD: Polymer science; Cell biology (FGU-C); Condensed matter physics (including formerly solid state physics, supercond.) (FZU-D)
Impakt faktor: 10.383, rok: 2021
Způsob publikování: Omezený přístup
Novel Yb,Tb,Nd-doped GdF3 and NaGdF4 nanoparticles were synthesized by a coprecipitation method in ethylene glycol (EG) in the presence of the poly(4-styrenesulfonic acid-co-maleic anhydride) stabilizer. The particle size and morphology, crystal structure, and phase change were controlled by adjusting the PSSMA concentration and source of fluoride anions in the reaction. Doping of Yb3+, Tb3+, and Nd3+ ions in the NaGdF4 host nanoparticles induced luminescence under ultraviolet and near-infrared excitation and high relaxivity in magnetic resonance (MR) imaging (MRI). In vitro toxicity of the nanoparticles and their cellular uptake efficiency were determined in model rat pancreatic β-cells (INS-1E). As the NaGdF4:Yb,Tb,Nd@PSSMA-EG nanoparticles were non-toxic and possessed good luminescence and magnetic properties, they were applicable for in vitro optical and MRI of isolated pancreatic islets in phantoms. The superior contrast was achieved for in vivoT2*-weighted MR images of the islets transplanted under the kidney capsule to mice in preclinical trials.
Trvalý link: http://hdl.handle.net/11104/0331806
Počet záznamů: 1