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Effects of high magnetic fields on the diffusion of biologically active molecules

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    0556091 - FZÚ 2023 RIV CH eng J - Článek v odborném periodiku
    Zablotskii, Vitalii - Polyakova, Tetyana - Dejneka, Alexandr
    Effects of high magnetic fields on the diffusion of biologically active molecules.
    Cells. Roč. 11, č. 1 (2022), č. článku 81. E-ISSN 2073-4409
    Grant CEP: GA MŠk(CZ) EF16_019/0000760
    Grant ostatní: OP VVV - SOLID21(XE) CZ.02.1.01/0.0/0.0/16_019/0000760
    Institucionální podpora: RVO:68378271
    Klíčová slova: magnetic field * molecular diffusion * drug diffusion * hemoglobin * red blood cells
    Obor OECD: Particles and field physics
    Impakt faktor: 7.666, rok: 2021
    Způsob publikování: Open access

    The diffusion of biologically active molecules is a ubiquitous process, controlling many mechanisms and the characteristic time scales for pivotal processes in living cells. Here, we show how a high static magnetic field (MF) affects the diffusion of paramagnetic and diamagnetic species including oxygen, hemoglobin, and drugs. We derive and solve the equation describing diffusion of such biologically active molecules in the presence of an MF as well as reveal the underlying mechanism of the MF’s effect on diffusion. We found that a high MF accelerates diffusion of diamagnetic species while slowing the diffusion of paramagnetic molecules in cell cytoplasm. When applied to oxygen and hemoglobin diffusion in red blood cells, our results suggest that an MF may significantly alter the gas exchange in an erythrocyte and cause swelling.
    Trvalý link: http://hdl.handle.net/11104/0330472

     
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