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Selective deficits in attentional set-shifting in mice induced by maternal immune activation with poly(I:C)

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    0555852 - FGÚ 2023 RIV NL eng J - Článek v odborném periodiku
    Malenínská, Kristýna - Janíková, Martina - Radostová, Dominika - Vojtěchová, Iveta - Petrásek, Tomáš - Kirdajová, Denisa - Anděrová, Miroslava - Svoboda, Jan - Stuchlík, Aleš
    Selective deficits in attentional set-shifting in mice induced by maternal immune activation with poly(I:C).
    Behavioural Brain Research. Roč. 419, 15 Feb (2022), č. článku 113678. ISSN 0166-4328. E-ISSN 1872-7549
    Grant CEP: GA ČR(CZ) GA19-03016S
    Institucionální podpora: RVO:67985823 ; RVO:68378041
    Klíčová slova: immunochallenge * poly(I:C) * maternal immune activation * cognitive deficit * schizophrenia * behavioral tests * mouse * interneurons * prenatal infection
    Obor OECD: Neurosciences (including psychophysiology
    Impakt faktor: 3.332, rok: 2020

    Maternal immune activation has been identified as a significant risk factor for schizophrenia. Using rodent models, past work has demonstrated various behavioral and brain impairments in offspring after immune-activating events. We applied 5 mg/kg of poly(I:C) on gestation day 9 to pregnant mouse dams, whose offspring were then stressed during puberty. We show impairments in attentional set-shifting in a T-maze, and a decreased number of parvalbumin-positive interneurons in the hippocampus as a result of peripubertal stress specifically in females.
    Trvalý link: http://hdl.handle.net/11104/0330313

     
     
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