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Caged Phytohormones: From Chemical Inactivation to Controlled Physiological Response
- 1.0552823 - ÚEB 2022 RIV US eng J - Článek v odborném periodiku
Hemelíková, Noemi - Žukauskaitė, A. - Pospíšil, T. - Strnad, Miroslav - Doležal, K. - Mik, V.
Caged Phytohormones: From Chemical Inactivation to Controlled Physiological Response.
Journal of Agricultural and Food Chemistry. Roč. 69, č. 41 (2021), s. 12111-12125. ISSN 0021-8561. E-ISSN 1520-5118
Grant CEP: GA MŠk(CZ) EF16_019/0000827
Institucionální podpora: RVO:61389030
Klíčová slova: caged compound * chemical biology * photochemistry * photoremovable protecting group * phytohormone * plant physiology
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 5.895, rok: 2021
Způsob publikování: Open access
Plant hormones, also called phytohormones, are small signaling molecules regulating a wide range of growth and developmental processes. These unique compounds respond to both external (light, temperature, water, nutrition, or pathogen attack) and internal factors (e.g., age) and mediate signal transduction leading to gene expression with the aim of allowing plants to adapt to constantly changing environmental conditions. Within the regulation of biological processes, individual groups of phytohormones act mostly through a web of interconnected responses rather than linear pathways, making elucidation of their mode of action in living organisms quite challenging. To further progress with our knowledge, the development of novel tools for phytohormone research is required. Although plenty of small molecules targeting phytohormone metabolic or signaling pathways (agonists, antagonists, and inhibitors) and labeled or tagged (fluorescently, isotopically, or biotinylated) compounds have been produced, the control over them in vivo is lost at the time of their administration. Caged compounds, on the other hand, represent a new approach to the development of small organic substances for phytohormone research. The term caged compounds refers to light-sensitive probes with latent biological activity, where the active molecule can be freed using a light beam in a highly spatio/temporal-, amplitude-, or frequency-defined manner. This review summarizes the up-to-date development in the field of caged plant hormones. Research progress is arranged in chronological order for each phytohormone regardless of the cage compound formulation and bacterial/plant/animal cell applications. Several known drawbacks and possible directions for future research are highlighted.
Trvalý link: http://hdl.handle.net/11104/0327914
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