Počet záznamů: 1
Fluorinated Ferrocene Moieties as a Platform for Redox-Responsive Polymer 19F MRI Theranostics
- 1.0552363 - ÚOCHB 2023 RIV US eng J - Článek v odborném periodiku
Švec, P. - Petrov, O. V. - Lang, J. - Štěpnička, P. - Groborz, Ondřej - Dunlop, David - Blahut, J. - Kolouchová, K. - Loukotová, Lenka - Sedláček, O. - Heizer, T. - Tošner, Z. - Šlouf, M. - Beneš, H. - Hoogenboom, R. - Hrubý, M.
Fluorinated Ferrocene Moieties as a Platform for Redox-Responsive Polymer 19F MRI Theranostics.
Macromolecules. Roč. 55, č. 2 (2022), s. 658-671. ISSN 0024-9297. E-ISSN 1520-5835
Grant CEP: GA MŠMT(CZ) LM2018133
Grant ostatní: AV ČR(CZ) StrategieAV21/6; AV ČR(CZ) StrategieAV21/10
Program: StrategieAV; StrategieAV
Institucionální podpora: RVO:61388963
Klíčová slova: magnetic resonance * molecular oxygen * ROS
Obor OECD: Organic chemistry
Impakt faktor: 5.5, rok: 2022
Způsob publikování: Omezený přístup
https://doi.org/10.1021/acs.macromol.1c01723
Fluorine-19 magnetic resonance imaging (19F MRI) stands out as a powerful tool for noninvasive diagnostics. In particular, polymer-based 19F MRI tracers offer tunable physicochemical properties, including solubility and thermoresponsiveness, and enhanced 19F MRI performance. However, these tracers do not detectably respond to redox changes or do so in only one redox state, thereby preventing potential applications to reactive oxygen species (ROS) bioimaging. Herein, we report the first amphiphilic redox-responsive, poly(2-oxazoline)-based polymers bearing fluorinated ferrocene moieties. Their hydrophobicity and redox responsiveness were tailored by changing the monomer ratio and substitution pattern of the fluorinated ferrocene units. Converting the diamagnetic fluorinated ferrocene moieties into paramagnetic ferrocenium markedly changed the chemical shift and relaxation times of the 19F nuclei distinguishable by 19F MRI. In turn, the statistical–diblock copolymers formed nanoparticles that disassemble upon oxidation, with no toxicity to cultured cells. Therefore, these polymers may be used to release lipophilic drugs in ROS-rich malignancies.
Trvalý link: http://hdl.handle.net/11104/0327510
Počet záznamů: 1