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Age-Dependent Changes in the Function of Mitochondrial Membrane Permeability Transition Pore in Rat Liver Mitochondria

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    0552140 - FGÚ 2022 RIV CZ eng J - Článek v odborném periodiku
    Endlicher, R. - Drahota, Zdeněk - Kučera, O. - Červinková, Z.
    Age-Dependent Changes in the Function of Mitochondrial Membrane Permeability Transition Pore in Rat Liver Mitochondria.
    Physiological Research. Roč. 70, č. 6 (2021), s. 905-911. ISSN 0862-8408. E-ISSN 1802-9973
    Institucionální podpora: RVO:67985823
    Klíčová slova: rat liver mitochondria * mitochondrial permeability transition pore * calcium retention capacity * calcium-induced swelling
    Obor OECD: Physiology (including cytology)
    Impakt faktor: 2.139, rok: 2021
    Způsob publikování: Open access
    https://www.biomed.cas.cz/physiolres/pdf/2021/70_905.pdf

    Mitochondria play an important role in the cell aging process. Changes in calcium homeostasis and/or increased reactive oxygen species (ROS) production lead to the opening of mitochondrial permeability transition pore (MPTP), depolarization of the inner mitochondrial membrane, and decrease of ATP production. Our work aimed to monitor age-related changes in the Ca2+ ion effect on MPTP and the ability of isolated rat liver mitochondria to accumulate calcium. The mitochondrial calcium retention capacity (CRC) was found to be significantly affected by the age of rats. Measurement of CRC values of the rat liver mitochondria showed two periods when 3 to 17-week old rats were tested. 3-week and 17-week old rats showed lower CRC values than 7-week old animals. Similar changes were observed while testing calcium-induced swelling of rat liver mitochondria. These findings indicate that the mitochondrial energy production system is more resistant to calcium-induced MPTP opening accompanied by the damaging effect of ROS in adult rats than in young and aged animals.
    Trvalý link: http://hdl.handle.net/11104/0327292

     
     
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