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Antibacterial Nanoparticles with Natural Photosensitizers Extracted from Spinach Leaves
- 1.0551259 - ÚFCH JH 2023 RIV US eng J - Článek v odborném periodiku
Ludačka, P. - Kubát, Pavel - Bosáková, Z. - Mosinger, J.
Antibacterial Nanoparticles with Natural Photosensitizers Extracted from Spinach Leaves.
ACS Omega. Roč. 7, č. 1 (2022), s. 1505-1513. ISSN 2470-1343. E-ISSN 2470-1343
Grant CEP: GA ČR(CZ) GA19-09721S
Grant ostatní: GA MŠk(CZ) CZ.02.1.01/0.0/0.0/15_003/0000417
Institucionální podpora: RVO:61388955
Klíčová slova: singlet oxygen * photodynamic therapy * molecular-oxygen * chlorophyll * carotenoids * phthalocyanines * polystyrene * derivatives * yields * state
Obor OECD: Physical chemistry
Impakt faktor: 4.1, rok: 2022
Způsob publikování: Open access
http://hdl.handle.net/11104/0326699http://hdl.handle.net/11104/0326699
We prepared antibacterial polystyrene nanoparticles (NPs) with natural photosensitizers from chlorophyll (Chl) extract via a simple nanoprecipitation method using the same solvent for dissolution of the polystyrene matrix and extraction of Chls from spinach leaves. A high photo-oxidation and antibacterial effect was demonstrated on Escherichia coli and was based on the photo generation of singlet oxygen O-2((1)Delta(g)), which was directly monitored by NIR luminescence measurements and indirectly verified using a chemical trap. The photoactivity of NPs was triggered by visible light, with enhanced red absorption by Chls. To reduce the quenching effect of carotenoids (beta-carotene, lutein, etc.) in the Chl extract, diluted and/or preirradiated samples, in which the photo-oxidized carotenoids lose their quenching effect, were used for preparation of the NPs. For enhanced photo-oxidation and antibacterial effects, a sulfonated polystyrene matrix was used for preparation of a stable dispersion of sulfonated NPs, with the quenching effect of carotenoids being suppressed.
Trvalý link: http://hdl.handle.net/11104/0326699
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