Multifunctional electrospun nanofibers based on biopolymer blends and magnetic tubular halloysite for medical applications

0549464 - BC 2022 RIV CH eng J - Článek v odborném periodiku
Khunová, V. - Pavliňák, D. - Šafařík, Ivo - Škrátek, M. - Ondreáš, F.
Multifunctional electrospun nanofibers based on biopolymer blends and magnetic tubular halloysite for medical applications.
Polymers. Roč. 13, č. 22 (2021), č. článku 3870. E-ISSN 2073-4360
Institucionální podpora: RVO:60077344
Klíčová slova: magnetic * halloysite * nanotubes * nanofibers * biopolymer * polycaprolactone * gelatine * electrospinning
Obor OECD: Materials engineering
Impakt faktor: 4.967, rok: 2021
Způsob publikování: Open access
https://www.mdpi.com/2073-4360/13/22/3870

Tubular halloysite (HNT) is a naturally occurring aluminosilicate clay with a unique combination of natural availability, good biocompatibility, high mechanical strength, and functionality. This study explored the effects of magnetically responsive halloysite (MHNT) on the structure, morphology, chemical composition, and magnetic and mechanical properties of electrospun nanofibers based on polycaprolactone (PCL) and gelatine (Gel) blends. MHNT was prepared via a simple modification of HNT with a perchloric-acid-stabilized magnetic fluid-methanol mixture. PCL/Gel nanofibers containing 6, 9, and 12 wt.% HNT and MHNT were prepared via an electrospinning process, respecting the essential rules for medical applications. The structure and properties of the prepared nanofibers were studied using infrared spectroscopy (ATR-FTIR) and electron microscopy (SEM, STEM) along with energy-dispersive X-ray spectroscopy (EDX), magnetometry, and mechanical analysis. It was found that the incorporation of the studied concentrations of MHNT into PCL/Gel nanofibers led to soft magnetic biocompatible materials with a saturation magnetization of 0.67 emu/g and coercivity of 15 Oe for nanofibers with 12 wt.% MHNT. Moreover, by applying both HNT and MHNT, an improvement of the nanofibers structure was observed, together with strong reinforcing effects. The greatest improvement was observed for nanofibers containing 9 wt.% MHNT when increases in tensile strength reached more than two-fold and the elongation at break reached a five-fold improvement.
Trvalý link: http://hdl.handle.net/11104/0325544