Minoxidil decreases collagen I deposition and tissue-like contraction in clubfoot-derived cells: a way to improve conservative treatment of relapsed clubfoot?

0547576 - FGÚ 2022 RIV US eng J - Článek v odborném periodiku
Knitlová, Jarmila - Doubková, Martina - Plencner, Martin - Vondrášek, David - Eckhardt, Adam - Ošťádal, M. - Musílková, Jana - Bačáková, Lucie - Novotný, T.
Minoxidil decreases collagen I deposition and tissue-like contraction in clubfoot-derived cells: a way to improve conservative treatment of relapsed clubfoot?
Connective Tissue Research. Roč. 62, č. 5 (2021), s. 554-569. ISSN 0300-8207. E-ISSN 1607-8438
Grant CEP: GA MZd(CZ) NV17-31564A; GA MŠMT(CZ) LM2015062
Institucionální podpora: RVO:67985823
Klíčová slova: relapsed clubfoot * congenital idiopathic talipes equinovarus * CTEV * fibrosis * minoxidil * collagen type I
Obor OECD: Orthopaedics
Impakt faktor: 3.342, rok: 2021
Způsob publikování: Open access
https://doi.org/10.1080/03008207.2020.1816992

Clubfoot is a congenital deformity affecting the musculoskeletal system, resulting in contracted and stiff tissue in the medial part of the foot. Minoxidil (MXD) has an inhibitory effect on lysyl hydroxylase, which influences the quality of extracellular matrix crosslinking, and could therefore be used to reduce the stiffness and to improve the flexibility of the tissue. We assessed the in vitro antifibrotic effects of minoxidil on clubfoot-derived cells.
Trvalý link: http://hdl.handle.net/11104/0323791