New metabolites of diclofenac found in pea and maize

0544663 - ÚVGZ 2022 CZ eng A - Abstrakt
Oravec, Michal - Mlynek, F. - Sendecká, Katarína - Buchberger, W. - Klampfl, W.CH. - Zezulka, Š. - Tříska, Jan
New metabolites of diclofenac found in pea and maize.
Plant Biology CS 2019 - Programme and Book of Abstracts. České Budějovice: Karmášek s.r.o., 2019 - (Krekule, J.). s. 151-151. ISSN 1213-6670.
[Plant Biology CS 2019. 25.08.2019-30.08.2019, České Budějovice]
Grant CEP: GA ČR(CZ) GF17-33746L; GA MŠMT(CZ) LO1415
Institucionální podpora: RVO:86652079
Klíčová slova: pea * pisum sativum * metabolites * pharmaceuticals * diclofenac
Obor OECD: Plant sciences, botany
https://www.plantbiologycs.cz/

Introduction: Pharmaceuticals are used widely in our society. They can be also detected at trace levels in waste water. Unfortunately, waste water treatment technology is still not able to remove these foreign substances. Due to rising drought in Europe, usage of waste water for irrigation is increasing in many countries. That is why plants get into contact with residuals of drugs. Another way how pharmaceuticals enter the agriculture is to use biosolids from animal production. One of the most worldwide consumed pharmaceutical groups are non-steroidal antiinflammatory drugs (NSAIDs). Diclofenac (DCF) is one of the most prescribed member of NSAIDs. Metabolomics provide information how plants deal with stress caused by biotic and abiotic factors, whether it is detection of new metabolite formation, phytohormones or change in levels of primary metabolites. In our research we focused on detection of plant metabolites of DCF formed during growth of maize and pea seedlings. There is information about uptake and few metabolites of DCF in horse radish (Armoracia rusticana), barley (Hordeum vulgare), Typha latifolia, cress (Lepidum sativum) and Arabidopsis thaliana. The knowledge of more metabolites is limited. Therefore our main goal was to investigate other metabolites of DCF, based on the preliminary results of our collaborator.
Trvalý link: http://hdl.handle.net/11104/0321497