Počet záznamů: 1  

Small-wedge synchrotron and serial XFEL datasets for Cysteinyl leukotriene GPCRs

  1. 1.
    0543374 - FZÚ 2022 RIV GB eng J - Článek v odborném periodiku
    Marin, E. - Luginina, A. - Gusach, A. - Kovalev, K. - Bukhdruker, S. - Khorn, P. - Polovinkin, Vitaly - Lyapina, E. - Rogachev, A. - Gordeliy, V. - Mishin, A. - Cherezov, V. - Borshchevskiy, V.
    Small-wedge synchrotron and serial XFEL datasets for Cysteinyl leukotriene GPCRs.
    Scientific Data. Roč. 7, č. 1 (2020), č. článku 388. ISSN 2052-4463. E-ISSN 2052-4463
    Grant CEP: GA MŠMT EF15_003/0000447; GA MŠMT LQ1606
    Grant ostatní: OP VVV - ELIBIO(XE) CZ.02.1.01/0.0/0.0/15_003/0000447
    Institucionální podpora: RVO:68378271
    Klíčová slova: data-collection * membrane-proteins * crystals * models
    Obor OECD: Polymer science
    Impakt faktor: 6.444, rok: 2020
    Způsob publikování: Open access

    Structural studies of challenging targets such as G protein-coupled receptors (GPCRs) have accelerated during the last several years due to the development of new approaches, including small-wedge and serial crystallography. Here, we describe the deposition of seven datasets consisting of X-ray diffraction images acquired from lipidic cubic phase (LCP) grown microcrystals of two human GPCRs, Cysteinyl leukotriene receptors 1 and 2 (CysLT(1)R and CysLT(2)R), in complex with various antagonists. Five datasets were collected using small-wedge synchrotron crystallography (SWSX) at the European Synchrotron Radiation Facility with multiple crystals under cryo-conditions. Two datasets were collected using X-ray free electron laser (XFEL) serial femtosecond crystallography (SFX) at the Linac Coherent Light Source, with microcrystals delivered at room temperature into the beam within LCP matrix by a viscous media microextrusion injector.

    Trvalý link: http://hdl.handle.net/11104/0320589

     
    Název souboruStaženoVelikostKomentářVerzePřístup
    0543374.pdf27.9 MBLicence CCVydavatelský postprintpovolen
     
Počet záznamů: 1  

  Tyto stránky využívají soubory cookies, které usnadňují jejich prohlížení. Další informace o tom jak používáme cookies.