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Small-wedge synchrotron and serial XFEL datasets for Cysteinyl leukotriene GPCRs
- 1.0543374 - FZÚ 2022 RIV GB eng J - Článek v odborném periodiku
Marin, E. - Luginina, A. - Gusach, A. - Kovalev, K. - Bukhdruker, S. - Khorn, P. - Polovinkin, Vitaly - Lyapina, E. - Rogachev, A. - Gordeliy, V. - Mishin, A. - Cherezov, V. - Borshchevskiy, V.
Small-wedge synchrotron and serial XFEL datasets for Cysteinyl leukotriene GPCRs.
Scientific Data. Roč. 7, č. 1 (2020), č. článku 388. ISSN 2052-4463. E-ISSN 2052-4463
Grant CEP: GA MŠMT EF15_003/0000447; GA MŠMT LQ1606
Grant ostatní: OP VVV - ELIBIO(XE) CZ.02.1.01/0.0/0.0/15_003/0000447
Institucionální podpora: RVO:68378271
Klíčová slova: data-collection * membrane-proteins * crystals * models
Obor OECD: Polymer science
Impakt faktor: 6.444, rok: 2020
Způsob publikování: Open access
Structural studies of challenging targets such as G protein-coupled receptors (GPCRs) have accelerated during the last several years due to the development of new approaches, including small-wedge and serial crystallography. Here, we describe the deposition of seven datasets consisting of X-ray diffraction images acquired from lipidic cubic phase (LCP) grown microcrystals of two human GPCRs, Cysteinyl leukotriene receptors 1 and 2 (CysLT(1)R and CysLT(2)R), in complex with various antagonists. Five datasets were collected using small-wedge synchrotron crystallography (SWSX) at the European Synchrotron Radiation Facility with multiple crystals under cryo-conditions. Two datasets were collected using X-ray free electron laser (XFEL) serial femtosecond crystallography (SFX) at the Linac Coherent Light Source, with microcrystals delivered at room temperature into the beam within LCP matrix by a viscous media microextrusion injector.
Trvalý link: http://hdl.handle.net/11104/0320589
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