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Magnetic superporous poly(2-hydroxyethyl methacrylate) hydrogel scaffolds for bone tissue engineering

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    0542997 - ÚMCH 2022 RIV CH eng J - Článek v odborném periodiku
    Zasońska, Beata Anna - Brož, Antonín - Šlouf, Miroslav - Hodan, Jiří - Petrovský, Eduard - Hlídková, Helena - Horák, Daniel
    Magnetic superporous poly(2-hydroxyethyl methacrylate) hydrogel scaffolds for bone tissue engineering.
    Polymers. Roč. 13, č. 11 (2021), č. článku 1871. E-ISSN 2073-4360
    Grant CEP: GA ČR(CZ) GA20-07015S
    Institucionální podpora: RVO:61389013 ; RVO:67985823 ; RVO:67985530
    Klíčová slova: poly(2-hydroxyethyl methacrylate) * superporous * scaffold
    Obor OECD: Polymer science; Biomaterials (as related to medical implants, devices, sensors) (FGU-C); Physical geography (GFU-E)
    Impakt faktor: 4.967, rok: 2021
    Způsob publikování: Open access
    https://www.mdpi.com/2073-4360/13/11/1871

    Magnetic maghemite (γ-Fe2O3) nanoparticles obtained by a coprecipitation of iron chlorides were dispersed in superporous poly(2-hydroxyethyl methacrylate) scaffolds containing continuous pores prepared by the polymerization of 2-hydroxyethyl methacrylate (HEMA) and ethylene dimethacrylate (EDMA) in the presence of ammonium oxalate porogen. The scaffolds were thoroughly characterized by scanning electron microscopy (SEM), vibrating sample magnetometry, FTIR spectroscopy, and mechanical testing in terms of chemical composition, magnetization, and mechanical properties. While the SEM microscopy confirmed that the hydrogels contained communicating pores with a length of ≤2 mm and thickness of ≤400 μm, the SEM/EDX microanalysis documented the presence of γ-Fe2O3 nanoparticles in the polymer matrix. The saturation magnetization of the magnetic hydrogel reached 2.04 Am2/kg, which corresponded to 3.7 wt.% of maghemite in the scaffold. The shape of the hysteresis loop and coercivity parameters suggested the superparamagnetic nature of the hydrogel. The highest toughness and compressive modulus were observed with γ-Fe2O3-loaded PHEMA hydrogels. Finally, the cell seeding experiments with the human SAOS-2 cell line showed a rather mediocre cell colonization on the PHEMA-based hydrogel scaffolds. However, the incorporation of γ-Fe2O3 nanoparticles into the hydrogel improved the cell adhesion significantly. This could make this composite a promising material for bone tissue engineering.
    Trvalý link: http://hdl.handle.net/11104/0320632

     
     
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