Comparison of macro-, micro- and nanomechanical properties of clinically-relevant UHMWPE formulations

0542837 - ÚMCH 2022 RIV NL eng J - Článek v odborném periodiku
Šlouf, Miroslav - Arevalo, S. - Vlková, Helena - Gajdošová, Veronika - Králík, V. - Pruitt, L.
Comparison of macro-, micro- and nanomechanical properties of clinically-relevant UHMWPE formulations.
Journal of the Mechanical Behavior of Biomedical Materials. Roč. 120, August (2021), č. článku 104205. ISSN 1751-6161. E-ISSN 1878-0180
Grant CEP: GA MZd(CZ) NV15-31269A; GA MŠMT(CZ) LO1507
Institucionální podpora: RVO:61389013
Klíčová slova: UHMWPE * macro- * micro- and nanomechanical properties
Obor OECD: Polymer science
Impakt faktor: 4.042, rok: 2021
Způsob publikování: Omezený přístup
https://www.sciencedirect.com/science/article/pii/S1751616120307475?via%3Dihub

We characterized a set of eleven clinically relevant formulations of UHMWPE for total joint replacements. Although their molecular and supermolecular structure were quite similar as evidenced by IR, DSC and SAXS measurements, there were slight differences in their crystallinity (DSC crystallinity ranging from 52 to 61%), which were connected with processing conditions, such as the total radiation dose, thermal treatment and/or addition of biocompatible stabilizers. Mechanical properties were assessed at all length scales, using macroscale compression testing, non-instrumented and instrumented microindentation hardness testing (at loading forces ~500 mN), and nanoindentation hardness testing measured at both higher and lower loading (~4 mN and ~0.6 mN, respectively). In agreement with theoretical predictions, we found linear correlations between UHMWPE crystallinity and its stiffness-related properties (elastic moduli, yield stress, and hardness) at all length scales (macro-, micro- and nanoscale). Detailed statistical evaluation of our dataset showed that the accuracy and precision of the applied methods decreased in the following order: non-instrumented microindentation ≥ instrumented microindentation ≥ macromechanical properties ≥ nanoindentation measured at higher loading forces ≫ nanoindentation measured at lower loading forces. The results confirm that microindentation and nanoindentation at sufficiently high loading forces are reliable methods, suitable for UHMWPE characterization.
Trvalý link: http://hdl.handle.net/11104/0320419