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Circadian regulation of transporter expression and implications for drug disposition

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    0542597 - FGÚ 2022 RIV GB eng J - Článek v odborném periodiku
    Pácha, Jiří - Balounová, Kateřina - Soták, M.
    Circadian regulation of transporter expression and implications for drug disposition.
    Expert Opinion on Drug Metabolism & Toxicology. Roč. 17, č. 4 (2021), s. 425-439. ISSN 1742-5255. E-ISSN 1744-7607
    Grant CEP: GA ČR(CZ) GA18-02993S
    Institucionální podpora: RVO:67985823
    Klíčová slova: drug transport * drug elimination * circadian rhythms * solute carriers * ATP-binding cassette transporters * liver * intestine * kidney
    Obor OECD: Physiology (including cytology)
    Impakt faktor: 4.936, rok: 2021
    Způsob publikování: Omezený přístup
    https://doi.org/10.1080/17425255.2021.1868438

    Introduction: Solute Carrier (SLC) and ATP-binding cassette (ABC) transporters expressed in the intestine, liver, and kidney determine the absorption, distribution, and excretion of drugs. In addition, most molecular and cellular processes show circadian rhythmicity controlled by circadian clocks that leads to diurnal variations in the pharmacokinetics and pharmacodynamics of many drugs and affects their therapeutic efficacy and toxicity.Area covered: This review provides an overview of the current knowledge on the circadian rhythmicity of drug transporters and the molecular mechanisms of their circadian control. Evidence for coupling drug transporters to circadian oscillators and the plausible candidates conveying circadian clock signals to target drug transporters, particularly transcription factors operating as the output of clock genes, is discussed.Expert opinion: The circadian machinery has been demonstrated to interact with the uptake and efflux of various drug transporters. The evidence supports the concept that diurnal changes that affect drug transporters may influence the pharmacokinetics of the drugs. However, more systematic studies are required to better define the timing of pharmacologically important drug transporter regulation and determine tissue- and sex-dependent differences. Finally, the transfer of knowledge based on the results and conclusions obtained primarily from animal models will require careful validation before it is applied to humans.
    Trvalý link: http://hdl.handle.net/11104/0319983

     
     
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