Effective control of optical purity by chiral HPLC separation for ester-based liquid crystalline materials forming anticlinic smectic phases

0541667 - FZÚ 2022 RIV GB eng J - Článek v odborném periodiku
Vojtylová-Jurkovičová, Terézia - Vaňkátová, Petra - Urbańska, M. - Hamplová, Věra - Sýkora, D. - Bubnov, Alexej
Effective control of optical purity by chiral HPLC separation for ester-based liquid crystalline materials forming anticlinic smectic phases.
Liquid Crystals. Roč. 48, č. 1 (2021), s. 43-53. ISSN 0267-8292. E-ISSN 1366-5855
Grant CEP: GA MŠMT(CZ) EF16_019/0000760; GA MŠMT(CZ) 8J20PL008; GA ČR GA19-03564S
Grant ostatní: OP VVV - SOLID21(XE) CZ.02.1.01/0.0/0.0/16_019/0000760; EU - ICT(XE) COST Action CA17139
Institucionální podpora: RVO:68378271
Klíčová slova: High-performance liquid chromatography * self-assembling behaviour * fluorinated materials * chiral liquid crystals * chiral separation * racemic mixtures
Obor OECD: Organic chemistry
Impakt faktor: 2.676, rok: 2021
Způsob publikování: Omezený přístup
https://doi.org/10.1080/02678292.2020.1762937

Effective control of optical purity by chiral separation of (S) and (R) enantiomers remains an actual and highlighted task while designing new chiral organic materials. An efficient methodology to solve this task has been developed and verified on a specifically designed series of chiral fluorinated liquid-crystalline materials with lateral substitution on the molecular core. HPLC was done using amylose based stationary phases. The self-assembling behaviour of new racemic materials was established. While establishing the chiral separation behaviour, the optimal separation conditions were taken over from our previous study and used for two chiral columns with coated amylose as chiral selector. Interestingly, two racemic materials demonstrated an unexpected change in enantiomer elution order. This is a very important information from separation point of view, e.g. preparative chiral chromatography.
Trvalý link: http://hdl.handle.net/11104/0319199