Ligands and Receptors Involved in the Sperm-Zona Pellucida Interactions in Mammals

0540510 - BTÚ 2021 RIV CH eng J - Článek v odborném periodiku
Tůmová, L. - Zigo, M. - Sutovsky, P. - Sedmíková, M. - Postlerová, Pavla
Ligands and Receptors Involved in the Sperm-Zona Pellucida Interactions in Mammals.
Cells. Roč. 10, č. 1 (2021), č. článku 133. E-ISSN 2073-4409
Grant CEP: GA ČR(CZ) GA18-11275S; GA MŠMT(CZ) ED1.1.00/02.0109
Institucionální podpora: RVO:86652036
Klíčová slova: glycoproteins * spermatozoa * zona pellucida * gamete interaction * sperm-ZP receptors * ZP-ligands
Obor OECD: Cell biology
Impakt faktor: 7.666, rok: 2021
Způsob publikování: Open access
https://www.mdpi.com/2073-4409/10/1/133

Sperm-zona pellucida (ZP) interaction, involving the binding of sperm surface ligands to complementary carbohydrates of ZP, is the first direct gamete contact event crucial for subsequent gamete fusion and successful fertilization in mammals. It is a complex process mediated by the coordinated engagement of multiple ZP receptors forming high-molecular-weight (HMW) protein complexes at the acrosomal region of the sperm surface. The present article aims to review the current understanding of sperm-ZP binding in the four most studied mammalian models, i.e., murine, porcine, bovine, and human, and summarizes the candidate ZP receptors with established ZP affinity, including their origins and the mechanisms of ZP binding. Further, it compares and contrasts the ZP structure and carbohydrate composition in the aforementioned model organisms. The comprehensive understanding of sperm-ZP interaction mechanisms is critical for the diagnosis of infertility and thus becomes an integral part of assisted reproductive therapies/technologies.
Trvalý link: http://hdl.handle.net/11104/0318135