0535240 - FGÚ 2021 RIV US eng J - Článek v odborném periodiku
Novotný, Tomáš - Eckhardt, Adam - Knitlová, Jarmila - Doubková, Martina - Ošťádal, M. - Uhlík, J. - Musílková, Jana
Increased Microvessel and Arteriole Density in the Contracted Side of the Relapsed Clubfoot.
Journal of Pediatric Orthopaedics. Roč. 40, č. 10 (2020), s. 592-596. ISSN 0271-6798. E-ISSN 1539-2570
Grant CEP: GA MZd(CZ) NV17-31564A
Institucionální podpora: RVO:67985823
Klíčová slova: clubfoot * microvessel density * arteriole density * proangiogenic factors * gene expression * immunohistochemistry
Obor OECD: Orthopaedics
Impakt faktor: 2.324, rok: 2020
Způsob publikování: Omezený přístup
https://journals.lww.com/pedorthopaedics/Abstract/2020/11000/Increased_Microvessel_and_Arteriole_Density_in_the.17.aspx

Clubfoot deformity (pes equinovarus) is one of the most common birth defects, and its etiology is still unknown. Initial clubfoot treatment is based on the Ponseti method throughout most of the world. Despite the effectiveness of this therapy, clubfoot may relapse. Recent studies confirm the theory of active fibrotic remodeling processes in the extracellular matrix of the affected tissue. The aim of this study was to clarify whether relapses in clubfoot therapy are associated with altered angiogenesis and to suggest possible regulatory pathways of this pathologic process.
Trvalý link: http://hdl.handle.net/11104/0313326