Počet záznamů: 1  

Internal structure of thermoresponsive physically crosslinked nanogel of poly[N-(2-hydroxypropyl)methacrylamide]-block-poly[N-(2,2-difluoroethyl)acrylamide], prominent 19F MRI tracer

  1. 1.
    0534443 - ÚMCH 2021 RIV CH eng J - Článek v odborném periodiku
    Babuka, David - Kolouchová, Kristýna - Groborz, Ondřej - Tosner, Z. - Zhigunov, Alexander - Štěpánek, Petr - Hrubý, Martin
    Internal structure of thermoresponsive physically crosslinked nanogel of poly[N-(2-hydroxypropyl)methacrylamide]-block-poly[N-(2,2-difluoroethyl)acrylamide], prominent 19F MRI tracer.
    Nanomaterials. Roč. 10, č. 11 (2020), s. 1-17, č. článku 2231. E-ISSN 2079-4991
    Grant CEP: GA MŠMT(CZ) LTC19032; GA ČR(CZ) GA19-01602S; GA ČR(CZ) GA18-07983S
    GRANT EU: European Commission(XE) 686089 - PRECIOUS
    Institucionální podpora: RVO:61389013
    Klíčová slova: fluorine-19 * magnetic resonance imaging * self-assembly
    Obor OECD: Polymer science
    Impakt faktor: 5.076, rok: 2020
    Způsob publikování: Open access
    https://www.mdpi.com/2079-4991/10/11/2231

    Fluorine-19 MRI is a promising noninvasive diagnostic method. However, the absence of a nontoxic fluorine-19 MRI tracer that does not suffer from poor biodistribution as a result of its strong fluorophilicity is a constant hurdle in the widespread applicability of this otherwise versatile diagnostic technique. The poly[N-(2-hydroxypropyl)methacrylamide]-block-poly[N-(2,2-difluoroethyl)acrylamide] thermoresponsive copolymer was proposed as an alternative fluorine-19 MRI tracer capable of overcoming such shortcomings. In this paper, the internal structure of self-assembled particles of this copolymer was investigated by various methods including 1D and 2D NMR, dynamic light scattering (DLS), small-angle X-ray scattering (SAXS) and small-angle neutron scattering (SANS). The elucidated structure appears to be that of a nanogel with greatly swollen hydrophilic chains and tightly packed thermoresponsive chains forming a network within the nanogel particles, which become more hydrophobic with increasing temperature. Its capacity to provide a measurable fluorine-19 NMR signal in its aggregated state at human body temperature was also investigated and confirmed. This capacity stems from the different fluorine-19 nuclei relaxation properties compared to those of hydrogen-1 nuclei.
    Trvalý link: http://hdl.handle.net/11104/0312876

     
     
Počet záznamů: 1  

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