Applications of Nanobiotechnology

0534391 - FGÚ 2021 RIV GB eng M - Část monografie knihy
Bačáková, Lucie - Zikmundová, Markéta - Pajorová, Julia - Brož, Antonín - Filová, Elena - Blanquer, Andreu - Matějka, Roman - Štěpanovská, Jana - Mikeš, P. - Jenčová, V. - Kuželová Košťáková, E. - Sinica, A.
Nanofibrous Scaffolds for Skin Tissue Engineering and Wound Healing Based on Synthetic Polymers.
Applications of Nanobiotechnology. London: IntechOpen, 2020 - (Stoytcheva, M.; Zlatev, R.), s. 1-29. ISBN 978-1-78985-978-2
Grant CEP: GA ČR(CZ) GA17-02448S; GA MZd(CZ) NV18-01-00332
Institucionální podpora: RVO:67985823
Klíčová slova: skin replacements * wound dressings * nanofibers * electrospinning * epidermis * dermis * keratinocytes * fibroblasts * stem cells * vascularization * cell delivery * drug delivery * regenerative medicine
Obor OECD: Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)
https://www.intechopen.com/books/applications-of-nanobiotechnology/nanofibrous-scaffolds-for-skin-tissue-engineering-and-wound-healing-based-on-synthetic-polymers

Nanofibrous scaffolds are popular materials in all areas of tissue engineering, because they mimic the fibrous component of the natural extracellular matrix. In this chapter, we focused on the application of nanofibers in skin tissue engineering and wound healing, because the skin is an organ with several vitally important functions, particularly barrier, thermoregulatory, and sensory functions. Nanofibrous meshes not only serve as carriers for skin cells but also can prevent the penetration of microbes into wounds and can keep appropriate moisture in the damaged skin. The nanofibrous meshes have been prepared from a wide range of synthetic and nature-derived polymers. This review is concentrated on synthetic non-degradable and degradable polymers, which have been explored for skin tissue engineering and wound healing. These synthetic polymers were often combined with natural polymers of the protein or polysaccharide nature, which improved their attractiveness for cell colonization. The nanofibrous scaffolds can also be loaded with various bioactive molecules, such as growth factors, hormones, vitamins, antioxidants, antimicrobial, and antitumor agents. In advanced tissue engineering approaches, the cells on the nanofibrous scaffolds are cultured in dynamic bioreactors enabling appropriate mechanical stimulation of cells and at air-liquid interface. This chapter summarizes recent results achieved in the field of nanofiber-based skin tissue engineering, including results of our research group.
Trvalý link: http://hdl.handle.net/11104/0312593