Počet záznamů: 1
Effect of Ni ion release on the cells in contact with NiTi alloys
- 1.0534086 - ÚFM 2021 RIV DE eng J - Článek v odborném periodiku
Veverková, J. - Bártková, Denisa - Weiser, Adam - Dlouhý, Antonín - Babula, P. - Štěpka, P. - Goldbergová, M. P.
Effect of Ni ion release on the cells in contact with NiTi alloys.
Environmental Science and Pollution Research. ROČ. 27, č. 8 (2020), s. 7934-7942. ISSN 0944-1344. E-ISSN 1614-7499
Grant CEP: GA ČR(CZ) GA15-16336S
Institucionální podpora: RVO:68081723
Klíčová slova: Nitinol * Cell * Biocompatibility * Biomaterial * Hydrogen modification
Obor OECD: Bioremediation, diagnostic biotechnologies (DNA chips and biosensing devices) in environmental management
Impakt faktor: 4.223, rok: 2020
Způsob publikování: Omezený přístup
https://link.springer.com/article/10.1007/s11356-019-07506-8
Nickel-titanium alloys have been used in medical applications for several years, however, biocompatibility of the material
remains controversial. In the present study, the human umbilical vein endothelial cells (HUVEC) were cultured in contact with
the nitinol used in two different heat treatment surface modifications—helium and hydrogen. The amount of Ni ions released
from these alloys in contact with HUVEC was measured in media and in the cells by ICP-MS. An increased release of Ni ions
was detected in He alloy compared with H2 alloy modification with an elevation with the metal exposition duration (24 h vs.
72 h). The cells contained the Ni ions in both selected alloy modifications with the lower levels in H2 alloys. To evaluate the
potential of multiple metal applications, similar values were observed in media and in cell suspension for all surface modification
combinations. The model analysis of effect of metal ion release on distant cells in the body showed that the concentration is
interestingly similar to concentrations in cells in direct contact with the metal alloy. The cells are able to regulate the concentration
of Ni ions within the cell. According to our best knowledge, the study for the first time describes the presence of Ni ions released
from nitinol directly in the cells. In the case of the H2 modification, the lowest levels of Ni ions were detected both in medium and
in the cells, which likely increases the biocompatibility of the nitinol alloy.
Trvalý link: http://hdl.handle.net/11104/0312304
Počet záznamů: 1