Polypeptides for the treatment of autoimmune diseases based on blocking the p19 subunit of the IL-23 human cytokine

0523549 - BTÚ 2020 RIV eng P - Patentový dokument
Malý, Petr - Křížová, Lucie - Kuchař, Milan - Petroková, Hana
Polypeptides for the treatment of autoimmune diseases based on blocking the p19 subunit of the IL-23 human cytokine.
2019. Vlastník: Biotechnologický ústav AV ČR, v. v. i. Datum udělení patentu: 15.05.2019. Číslo patentu: 307849B6
Institucionální podpora: RVO:86652036
Klíčová slova: p19 subunit * amino acids P, A, T, M, Q * IL-23 human cytokine
Obor OECD: Biochemistry and molecular biology
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The invention concerns a polypeptide suitable for treating autoimmune diseases comprising an amino acid sequence: XYKNXINXAXXVXXVKXXIDXILAXILAXLP (SEW ID NO. 1) with an alpha-helical structure directly attached to the N-terminus or C-terminus, where: X 1 is selected from amino acids V, I, P, S ., Xis selected from amino acids T, W, R, L, M, Xis selected from amino acids P, A, T, M, Q, Xis selected from amino acids A, S, G, V, Xis selected from amino acids W, G, T, F, L, Xis selected from amino acids L, R, A, Xis selected from amino acids A, H, L, Y, R, Xis selected from amino acids R, S, Xis selected from amino acids M, C, W, R, F, Xis selected from amino acids R, M, L, S, V, Xis selected from amino acids N, A, G, P, R.
Trvalý link: http://hdl.handle.net/11104/0307893