Počet záznamů: 1  

Primary sensory map formations reflect unique needs and molecular cues specific to each sensory system

  1. 1.
    0523096 - BTÚ 2020 RIV GB eng J - Článek v odborném periodiku
    Fritzsch, B. - Elliott, K. L. - Pavlínková, Gabriela
    Primary sensory map formations reflect unique needs and molecular cues specific to each sensory system.
    F1000Research. Roč. 8, č. 2019 (2019). ISSN 2046-1402
    Grant CEP: GA MŠMT(CZ) ED1.1.00/02.0109; GA ČR(CZ) GA17-04719S
    Institucionální podpora: RVO:86652036
    Klíčová slova: Cochleotopic map * Olfactory map * Primary sensory maps * Retinotopic map * Taste map * Vestibular map
    Obor OECD: Biochemistry and molecular biology
    Způsob publikování: Open access
    https://f1000research.com/articles/8-345/v1

    Interaction with the world around us requires extracting meaningful signals to guide behavior. Each of the six mammalian senses (olfaction, vision, somatosensation, hearing, balance, and taste) has a unique primary map that extracts sense-specific information. Sensory systems in the periphery and their target neurons in the central nervous system develop independently and must develop specific connections for proper sensory processing. In addition, the regulation of sensory map formation is independent of and prior to central target neuronal development in several maps. This review provides an overview of the current level of understanding of primary map formation of the six mammalian senses. Cell cycle exit, combined with incompletely understood molecules and their regulation, provides chemoaffinity-mediated primary maps that are further refined by activity. The interplay between cell cycle exit, molecular guidance, and activity-mediated refinement is the basis of dominance stripes after redundant organ transplantations in the visual and balance system. A more advanced level of understanding of primary map formation could benefit ongoing restoration attempts of impaired senses by guiding proper functional connection formations of restored sensory organs with their central nervous system targets.
    Trvalý link: http://hdl.handle.net/11104/0307501

     
     
Počet záznamů: 1  

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