Remote apoptosis resulted by external magnetic field in cancer cells loaded with magnetic nanoparticles as potential therapeutic method

0522426 - FZÚ 2020 US eng A - Abstrakt
Uzhytchak, Mariia - Lynnyková, Anna - Dempsey, N.M. - Dias, A. - Bonfim, M. - Smolková, Barbora - Lunova, M. - Jirsa, M. - Kubinová, Šárka - Lunov, Oleg - Dejneka, Alexandr
Remote apoptosis resulted by external magnetic field in cancer cells loaded with magnetic nanoparticles as potential therapeutic method.
FEBS Open Bio. Vol. 9. New Jersey: Wiley, 2019 - (De la Rosa, M.). s. 361-361. ISSN 2211-5463. E-ISSN 2211-5463.
[FEBS Congress, from Molecules to Living Systems /44./. 06.07.2019-11.07.2019, Krakov]
Institucionální podpora: RVO:68378271 ; RVO:68378041
Klíčová slova: SPIONS * MF * cancerous cells
Obor OECD: Biophysics; Oncology (UEM-P)

Magnetic nanoparticles, SPIONS (Superparamagnetic iron oxide nanoparticles) are known as potential delivery agents by virtue of its relatively low cytotoxicity, its paramagnetic properties and overall effectiveness. Previous studies prove, that application of MF (magnetic field) significantly enhance nanoparticles uptake by living cells. Moreover, it was reported recently that nanoparticle agglomerates are internalized with lysosomes in SPIONs loaded cancer cells. Together with application of MF these findings could be used as tentative method for the remotely controlled induction of cell death. Our work propose proof of concept in remote apoptosis induced by external pulsed MF in SPIONs-loaded cancerous cells. Our proof of concept displays potential methods for effective intracellular uptake and cell labelling within pulsed MF and provide promising tool for further remote apoptosis induction in biomedicine and cell signalling research.

Trvalý link: http://hdl.handle.net/11104/0306921