0518013 - ÚOCHB 2020 RIV eng P - Patentový dokument
Šácha, Pavel - Konvalinka, Jan - Schimer, Jiří - Knedlík, Tomáš - Navrátil, Václav - Tykvart, Jan - Sedlák, František - Majer, Pavel - Cígler, Petr - Šubr, Vladimír - Ulbrich, Karel - Strohalm, Jiří
Macromolecular conjugates for visualization and separation of proteins and cells.
2018. Vlastník: Ústav organické chemie a biochemie AV ČR, v. v. i. - Ústav makromolekulární chemie AV ČR, v. v. i. - Univerzita Karlova v Praze. Datum udělení patentu: 29.11.2018. Číslo patentu: AU2016207126
Grant CEP: GA ČR(CZ) GA16-02938S; GA MŠMT LO1302
Institucionální podpora: RVO:61388963 ; RVO:61389013
Klíčová slova: antibody mimetics * flow cytometry * ELISA * protein targeting * polymer conjugates * molecular recognition * HPMA
Obor OECD: Biochemistry and molecular biology; Polymer science (UMCH-V)
Web výsledku:
https://worldwide.espacenet.com/publicationDetails/originalDocument?FT=D&date=20181129&DB=&locale=en_EP&CC=AU&NR=2016207126B2&KC=B2&ND=5#

Macromolecular conjugates for visualization and separation of proteins and cells The present invention descripbes macromolecular water-soluble conjugates based on synthetic copolymers to which at least one affinity tag, at least one imaging probe and at least one targeting ligand are bound via covalent bonds. The macromolecular conjugate may be used in identification, visualization, quantification or isolation of proteins and/or cells both in vitro and in vivo. HPMA copolymer, i.e.poly(HPMA-co-Ma-β-Ala-TT), copolymer prepared by conventional solution radical polymerization or controlled radical copolymerization (e.g. RAFT copolymerization, reversible addition-fragmentation chain-transfer) of N-(2- hydroxypropyl)methacrylamide (HPMA) and 3-(3-methakrylamidopropanoyl)thiazolidine-2-thione (Ma-P-Ala-TT) can be preferably used as the basic copolymer.
Trvalý link: http://hdl.handle.net/11104/0303259